Max Human

Max Human Newsletter - Week 12 of 2025

Hello, Max here again!

Last week, we flipped the script with our Spring Challenge—daily bite-sized hits instead of one weekly info bomb. Some of you were into it. Others? Missed the deep dive. Majority vote says: bring back the beast. So here we are.

But we're not done experimenting. You might start seeing a 2-drop format: a fast-and-dirty teaser early in the week, and this thick, juicy deep dive to close it out.

This week: your gut is betraying you, your brain is waving a white flag, and sleep after 60? More like a house with a leaking roof. We're not here to scare you—we're here to arm you.

Let's go.🔥

This Week's Discoveries:

🦠 Your gut is aging like a wet sponge left in a warm kitchen. And it's messing with your immunity.
🧨 JNK is the biochemical version of that friend who helps you move, then robs your fridge. Context matters.
☕ A caffeine cousin is out here rewriting your cellular destiny. Seriously.
🩸 Your blood might know your brain's failing before you forget your own name.
⏪ Reprogramming cells isn't sci-fi. It's DIY biological time travel.
🫐 Polyphenols are doing more than making your smoothie fancy. They're age-fighting assassins.
📲 Firefighters beat diet culture using WhatsApp. No joke.
💨 Air pollution is frying your brain one breath at a time.
🧬 Liver cancer found its metabolic fuel source. Scientists just pulled the plug.
💤 Sleep after 60? It's not sleep. It's scheduled unconscious chaos.

STUDIES & ARTICLES

1️⃣ Your Gut Is Aging — And Turning On You

Illustration by DEBORA CHEYENNE CRUCHON

Your gut microbiome? Yeah, it's not aging gracefully. The peacekeepers are retiring, and inflammatory thugs like Enterobacteriaceae are moving in. The result? Leaky gut, chronic inflammation, immune dysfunction. You're basically digesting chaos.

Scientists gave young mice poop transplants from old mice—and instantly triggered aging symptoms. Reversing the transplant made old mice healthier. Gut bugs matter more than you think.

⚔️ Gut Control Tip: Feed your microbes like they matter—because they do. Fiber, fermented foods, and possibly next-gen probiotics. Fecal transplants? Only if you're hardcore.

🔗 Read more

Source: Nature Aging | Impact Factor: 16.6

2️⃣ The Molecular Double-Crosser

JNK is like that helpful neighbor who fixes your sink... and then steals your bike. This cellular stress responder can either protect you—or screw you over. Boost it in your brain or gut? Lifespan boost.

Turn it up in fat cells? Welcome to metabolic ruin. Context is everything, and JNK doesn't play nice everywhere.

💡 Target Smart: JNK-based therapies could slow aging—but only if we can hit the right tissues. Precision is the name of the game.

🔗 Read more

Source: Aging Cell | Impact Factor: 7.8

3️⃣ The Caffeine Cousin That Might Cheat Death

Meet XnD-1: a souped-up xanthine derivative that hits AMPK, chills mTOR, and rewires your aging clock. It extended lifespan in worms and mice, improved mitochondrial function, and reduced DNA damage.

Bonus? No sketchy side effects. It's like a decaf coffee that turns you immortal.

🔋 Energy Hack: Watch this molecule. Or mimic its effects with fasting, cold exposure, or other AMPK activators.

🔗 Read more

Source: Aging Cell | Impact Factor: 7.8

4️⃣ Your Blood Knows Your Brain Is Dying

dancing people hustling moving party genes healthy fun

Illustration by Esme Lower

Your brain is shrinking—and your blood's spilling the secret. In aging monkeys, rising plasma levels of tau, NfL, and GFAP matched brain atrophy and cognitive decline.

Inflammatory cytokines showed up before gray matter vanished. It's predictive, not reactive.

🧠 What To Do: Monitor biomarkers early. Intervene before brain fog turns into full-on erosion.

🔗 Read more

Source: Experimental Gerontology, IF: 5.1

5️⃣ Reprogramming Cells Is DIY Time Travel

You can't go back in time. But your cells can. By triggering partial reprogramming, scientists restored youthful gene expression—without wiping cellular identity or causing cancer.

Mitochondria, DNA repair, protein maintenance? All rebooted.

🧬 Big Idea: This isn't science fiction. It's a real path to reversing aging, one cell at a time. Watch this space.

🔗 Read more

Source: Cell Reports | Impact Factor: 9.8

6️⃣ Polyphenols Are Not Optional

Illustration by Jordan Kay

If you think polyphenols are just marketing fluff to sell you expensive olive oil, you've been played. These plant compounds reduce oxidative stress, kill senescent cells, enhance autophagy, and modulate key aging pathways.

In animals, they extend lifespan. In humans, they lower inflammation and improve metabolism.

🥦 Anti-Aging Upgrade: Eat the rainbow. Load up on berries, tea, dark chocolate, olive oil. These aren't garnishes—they're weapons.

🔗 Read more

Source: Trends in Pharmacological Sciences | IF: 15.2

7️⃣ WhatsApp Beat Doctors

Firefighters improved their diets and dropped pounds just by getting smart, stage-based texts through WhatsApp. No lectures. No coaching. Just the right info at the right time.

The result? Better eating habits and lower waistlines. Proof that your phone can coach you better than your doctor—if used right.

📱 Micro-Habit Hack: Use reminders, nudges, and smart content to shape your daily habits. It works. Science said so.

🔗 Read more

Source: Nutrition | IF: 4.6

8️⃣ Your Air Is Cooking Your Brain

Illustration by Sandro Rybak

Long-term PM2.5 exposure—those tiny invisible pollutants—raises your dementia risk by 14%+. Even "legal" pollution levels are frying your neurons.

Alzheimer's risk spikes. Vascular dementia gets sketchy. You're inhaling cognitive decline without realizing it.

🌬 Protect Your Brain: Air purifiers. HEPA filters. N95 masks. Whatever it takes—don't give your neurons away for free.

🔗 Read more

Source: Nature Aging | IF: 16.6

9️⃣ The Enzyme Fueling Liver Cancer

DLAT isn't just part of energy metabolism—it's helping liver tumors grow. It acetylates AUH, blocks leucine breakdown, and keeps the mTOR pathway running like a factory.

Researchers used modified mRNA to shut it down—and tumors shrank fast.

🧨 Oncology Hack: Cancer has metabolic weaknesses. Target them. DLAT is just the beginning.

🔗 Read more

Source: Cell Metabolism | IF: 31.4

🔟 Sleep After 60? A Hot Mess

After tracking people for 40 years, this study found your sleep basically collapses as you age. REM drops, deep sleep shrinks, wakefulness spikes. Sleep transitions? All over the place.

It's like your sleep goes from ballet to drunken karaoke.

🛏 Save Your Sleep: Stick to a strict routine. Optimize your sleep environment. Track and tweak relentlessly. Sleep is the keystone.

🔗 Read more

Source: Journal of Sleep Research | IF: 3.4

HEALTH HACK OF THE WEEK

🛏️ Want to age slower while unconscious?

Drop your room temp to 18°C, blackout everything, and ditch the screens an hour before bed. Your mitochondria will thank you. Your future self might even hug you.

HEALTH HACK OF THE

🦠 Your gut turns into a riot zone as you age. Keep it in check or pay the price.
🧨 JNK is a double agent. Activate wisely or prepare for friendly fire.
💊 Longevity in a pill? XnD-1 is looking like the real deal.
🩸 Blood biomarkers = early dementia snitches. Don't ignore them.
⏳ Reprogramming your cells might be the closest thing to immortality we've got.
🫐 Polyphenols are your edible armor against aging. Don't skip them.
📲 Behavioral nudges beat lectures. Especially if they come via memes.
💨 If you're breathing city air without a filter, your brain's already losing.
🧬 Metabolic sabotage is cancer's Achilles heel. Go for it.
😴 Your sleep is disintegrating. Defend it like your life depends on it. Because it does.

Thanks for sticking around for the real stuff. This isn't feel-good fluff or social media science. It's what your body and brain actually need.

See you next week!

Cheers,
–Max

Rate this week's newsletter on a scale:

⭐ Quick Win: Simple, no-fuss tips. I'll do it today.

⭐⭐ Game Changer: Medium effort, big results. Worth it.

⭐⭐⭐ Longevity Legend: Big moves for a better future.

ATTENTION: These aren't your usual clickbait headlines.
We're diving into peer-reviewed, trustworthy research that could genuinely help you live your best life. No hype, no paid media, just the real deal. No lower Impact Factor than 2.5.

Curious about how we choose our sources? You can always check out maxhuman.ai for all the nitty-gritty on our methods.

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<div class="header">
<div><strong>Week 12 of 2025:</strong> March 17-23</div>
<div><strong>Read time:</strong> under 10 minutes</div>
</div>
<div>
<p>Hello, Max here again!</p>
<p>Last week, we flipped the script with our Spring Challenge—daily bite-sized hits instead of one weekly info bomb. Some of you were into it. Others? Missed the deep dive. Majority vote says: bring back the beast. So here we are.</p>
<p><strong>But we're not done experimenting.</strong> You might start seeing a 2-drop format: a fast-and-dirty teaser early in the week, and this thick, juicy deep dive to close it out.</p>
<p><strong>This week:</strong> your gut is betraying you, your brain is waving a white flag, and sleep after 60? More like a house with a leaking roof. We're not here to scare you—we're here to arm you.</p>
<p>Let's go.🔥</p>
<hr>
<p><strong>This Week's Discoveries:</strong></p>
<ol>
<li>🦠 Your gut is aging like a wet sponge left in a warm kitchen. And it's messing with your immunity.</li>
<li>🧨 JNK is the biochemical version of that friend who helps you move, then robs your fridge. Context matters.</li>
<li>☕ A caffeine cousin is out here rewriting your cellular destiny. Seriously.</li>
<li>🩸 Your blood might know your brain's failing before you forget your own name.</li>
<li>⏪ Reprogramming cells isn't sci-fi. It's DIY biological time travel.</li>
<li>🫐 Polyphenols are doing more than making your smoothie fancy. They're age-fighting assassins.</li>
<li>📲 Firefighters beat diet culture using WhatsApp. No joke.</li>
<li>💨 Air pollution is frying your brain one breath at a time.</li>
<li>🧬 Liver cancer found its metabolic fuel source. Scientists just pulled the plug.</li>
<li>💤 Sleep after 60? It's not sleep. It's scheduled unconscious chaos.</li>
</ol>
</div>
</div>

<div class="content-box">
<div><a href="#" class="yellow-tag">STUDIES & ARTICLES</a></div>
<h2>1️⃣ Your Gut Is Aging — And Turning On You</h2>
<img src="https://i.pinimg.com/736x/64/da/ec/64daec06b9e805c4a5bbc9c13fe73d45.jpg" alt="brain energy booster puzzle heart">
<p class="caption">Illustration by <a href="https://www.instagram.com/rrrrrroche/?hl=en">DEBORA CHEYENNE CRUCHON</a></p>

<p>Your gut microbiome? Yeah, it's not aging gracefully. The peacekeepers are retiring, and inflammatory thugs like Enterobacteriaceae are moving in. The result? Leaky gut, chronic inflammation, immune dysfunction. You're basically digesting chaos.</p>
<p>Scientists gave young mice poop transplants from old mice—and instantly triggered aging symptoms. Reversing the transplant made old mice healthier. Gut bugs matter more than you think.</p>

<p><strong>⚔️ Gut Control Tip:</strong> Feed your microbes like they matter—because they do. Fiber, fermented foods, and possibly next-gen probiotics. Fecal transplants? Only if you're hardcore.</p>

<p>🔗 <a href="https://www.nature.com/articles/s43587-025-00844-y" class="read-more">Read more</a></p>
<p class="source">Source: Nature Aging | Impact Factor: 16.6</p>

<hr>

<h2>2️⃣ The Molecular Double-Crosser</h2>
<p>JNK is like that helpful neighbor who fixes your sink... and then steals your bike. This cellular stress responder can either protect you—or screw you over. Boost it in your brain or gut? Lifespan boost.</p>
<p>Turn it up in fat cells? Welcome to metabolic ruin. Context is everything, and JNK doesn't play nice everywhere.</p>

<p><strong>💡 Target Smart:</strong> JNK-based therapies could slow aging—but only if we can hit the right tissues. Precision is the name of the game.</p>

<p>🔗 <a href="https://onlinelibrary.wiley.com/doi/10.1111/acel.70049?af=R" class="read-more">Read more</a></p>
<p class="source">Source: Aging Cell | Impact Factor: 7.8</p>

<hr>

<h2>3️⃣ The Caffeine Cousin That Might Cheat Death</h2>
<p>Meet XnD-1: a souped-up xanthine derivative that hits AMPK, chills mTOR, and rewires your aging clock. It extended lifespan in worms and mice, improved mitochondrial function, and reduced DNA damage.</p>
<p>Bonus? No sketchy side effects. It's like a decaf coffee that turns you immortal.</p>

<p><strong>🔋 Energy Hack:</strong> Watch this molecule. Or mimic its effects with fasting, cold exposure, or other AMPK activators.</p>

<p>🔗 <a href="https://onlinelibrary.wiley.com/doi/10.1111/acel.70047?af=R" class="read-more">Read more</a></p>
<p class="source">Source: Aging Cell | Impact Factor: 7.8</p>

<hr>

<h2>4️⃣ Your Blood Knows Your Brain Is Dying</h2>
<img src="https://i.pinimg.com/736x/15/8b/94/158b94f246675aac52c03e690049bb93.jpg" alt="dancing people hustling moving party genes healthy fun">
<p class="caption">Illustration by <a href="https://www.itsnicethat.com/articles/esme-lower-illustration-discover-180723">Esme Lower</a></p>

<p>Your brain is shrinking—and your blood's spilling the secret. In aging monkeys, rising plasma levels of tau, NfL, and GFAP matched brain atrophy and cognitive decline.</p>
<p>Inflammatory cytokines showed up before gray matter vanished. It's predictive, not reactive.</p>

<p><strong>🧠 What To Do:</strong> Monitor biomarkers early. Intervene before brain fog turns into full-on erosion.</p>

<p>🔗 <a href="https://www.sciencedirect.com/science/article/pii/S0531556525000658?dgcid=rss_sd_all" class="read-more">Read more</a></p>
<p class="source">Source: Experimental Gerontology, IF: 5.1</p>

<hr>

<h2>5️⃣ Reprogramming Cells Is DIY Time Travel</h2>
<p>You can't go back in time. But your cells can. By triggering partial reprogramming, scientists restored youthful gene expression—without wiping cellular identity or causing cancer.</p>
<p>Mitochondria, DNA repair, protein maintenance? All rebooted.</p>

<p><strong>🧬 Big Idea:</strong> This isn't science fiction. It's a real path to reversing aging, one cell at a time. Watch this space.</p>

<p>🔗 <a href="https://www.sciencedirect.com/science/article/pii/S1568163725000832?dgcid=rss_sd_all" class="read-more">Read more</a></p>
<p class="source">Source: Cell Reports | Impact Factor: 9.8</p>

<hr>

<h2>6️⃣ Polyphenols Are Not Optional</h2>
<img src="https://i.pinimg.com/736x/39/4f/47/394f47a01a871359d843c7112ac9e241.jpg" alt="polyphenols illustration">
<p class="caption">Illustration by <a href="https://dribbble.com/msjordankay">Jordan Kay</a></p>

<p>If you think polyphenols are just marketing fluff to sell you expensive olive oil, you've been played. These plant compounds reduce oxidative stress, kill senescent cells, enhance autophagy, and modulate key aging pathways.</p>
<p>In animals, they extend lifespan. In humans, they lower inflammation and improve metabolism.</p>

<p><strong>🥦 Anti-Aging Upgrade:</strong> Eat the rainbow. Load up on berries, tea, dark chocolate, olive oil. These aren't garnishes—they're weapons.</p>

<p>🔗 <a href="https://www.sciencedirect.com/science/article/pii/S1568163725000790?dgcid=rss_sd_all" class="read-more">Read more</a></p>
<p class="source">Source: Trends in Pharmacological Sciences | IF: 15.2</p>

<hr>

<h2>7️⃣ WhatsApp Beat Doctors</h2>
<p>Firefighters improved their diets and dropped pounds just by getting smart, stage-based texts through WhatsApp. No lectures. No coaching. Just the right info at the right time.</p>
<p>The result? Better eating habits and lower waistlines. Proof that your phone can coach you better than your doctor—if used right.</p>

<p><strong>📱 Micro-Habit Hack:</strong> Use reminders, nudges, and smart content to shape your daily habits. It works. Science said so.</p>

<p>🔗 <a href="https://www.sciencedirect.com/science/article/pii/S0899900725000826?via%3Dihub" class="read-more">Read more</a></p>
<p class="source">Source: Nutrition | IF: 4.6</p>

<hr>

<h2>8️⃣ Your Air Is Cooking Your Brain</h2>
<img src="https://i.pinimg.com/736x/25/a7/25/25a725f2d589e2ebaeeb9f2a5f189795.jpg" alt="mitochondria feeding shower stress">
<p class="caption">Illustration by <a href="https://www.behance.net/SandroRybak">Sandro Rybak</a></p>

<p>Long-term PM2.5 exposure—those tiny invisible pollutants—raises your dementia risk by 14%+. Even "legal" pollution levels are frying your neurons.</p>
<p>Alzheimer's risk spikes. Vascular dementia gets sketchy. You're inhaling cognitive decline without realizing it.</p>

<p><strong>🌬 Protect Your Brain:</strong> Air purifiers. HEPA filters. N95 masks. Whatever it takes—don't give your neurons away for free.</p>

<p>🔗 <a href="https://www.nature.com/articles/s43587-025-00844-y" class="read-more">Read more</a></p>
<p class="source">Source: Nature Aging | IF: 16.6</p>

<hr>

<h2>9️⃣ The Enzyme Fueling Liver Cancer</h2>
<p>DLAT isn't just part of energy metabolism—it's helping liver tumors grow. It acetylates AUH, blocks leucine breakdown, and keeps the mTOR pathway running like a factory.</p>
<p>Researchers used modified mRNA to shut it down—and tumors shrank fast.</p>

<p><strong>🧨 Oncology Hack:</strong> Cancer has metabolic weaknesses. Target them. DLAT is just the beginning.</p>

<p>🔗 <a href="https://www.sciencedirect.com/science/article/pii/S155041312500066X?via%3Dihub" class="read-more">Read more</a></p>
<p class="source">Source: Cell Metabolism | IF: 31.4</p>

<hr>

<h2>🔟 Sleep After 60? A Hot Mess</h2>
<p>After tracking people for 40 years, this study found your sleep basically collapses as you age. REM drops, deep sleep shrinks, wakefulness spikes. Sleep transitions? All over the place.</p>
<p>It's like your sleep goes from ballet to drunken karaoke.</p>

<p><strong>🛏 Save Your Sleep:</strong> Stick to a strict routine. Optimize your sleep environment. Track and tweak relentlessly. Sleep is the keystone.</p>

<p>🔗 <a href="https://onlinelibrary.wiley.com/doi/10.1111/jsr.70039" class="read-more">Read more</a></p>
<p class="source">Source: Journal of Sleep Research | IF: 3.4</p>


<div class="promo-box">
<p><span style="font-size:12px;font-weight:700">In partnership with GlycanAge</span></p>
<h3>How Old Is Your Immune System? GlycanAge Knows.</h3>
<img src="https://d3k81ch9hvuctc.cloudfront.com/company/WWuhph/images/8be1d8e4-60aa-4dfe-a975-7024e5d1048d.png" alt="Immune System Insights">
<p class="caption">Illustration by Andrei Nicolescu</p>
<p>Want to know if your health routine is actually working? <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4049143/"><strong>GlycanAge cuts through the guesswork and shows you how well you're aging</strong></a>—for real. By measuring your immune system's biological age, it reveals how your lifestyle choices impact your health. Think of it as your personal age detective, minus the trench coat.</p>
<p><strong>Ready to level up your health?</strong> Take control of your aging journey and see the science in action. Plus, we've got an exclusive deal for you—get 10% off with code MAXHUMAN.</p>
<a href="https://glycanage.com/price-and-plans?discount=MAXHUMAN" style="display:block;background:#ddc9ff;color:#000;padding:10px;border:1px solid #000;border-radius:5px;text-align:center;font-weight:700;text-decoration:none;margin-top:15px">Get the Deal</a>
</div>
</div>


<div class="content-box">
<a href="#" class="yellow-tag">HEALTH HACK OF THE WEEK</a>
<h2>🛏️ Want to age slower while unconscious?</h2>
<p>Drop your room temp to 18°C, blackout everything, and ditch the screens an hour before bed. Your mitochondria will thank you. Your future self might even hug you.</p>
</div>


<div class="content-box">
<a href="#" class="yellow-tag">HEALTH HACK OF THE</a>
<ul>
<li>🦠 <strong>Your gut turns into a riot zone as you age.</strong> Keep it in check or pay the price.</li>
<li>🧨 <strong>JNK is a double agent.</strong> Activate wisely or prepare for friendly fire.</li>
<li>💊 <strong>Longevity in a pill?</strong> XnD-1 is looking like the real deal.</li>
<li>🩸 <strong>Blood biomarkers = early dementia snitches.</strong> Don't ignore them.</li>
<li>⏳ <strong>Reprogramming your cells</strong> might be the closest thing to immortality we've got.</li>
<li>🫐 <strong>Polyphenols are your edible armor against aging.</strong> Don't skip them.</li>
<li>📲 <strong>Behavioral nudges beat lectures.</strong> Especially if they come via memes.</li>
<li>💨 <strong>If you're breathing city air without a filter,</strong> your brain's already losing.</li>
<li>🧬 <strong>Metabolic sabotage is cancer's Achilles heel.</strong> Go for it.</li>
<li>😴 <strong>Your sleep is disintegrating.</strong> Defend it like your life depends on it. Because it does.</li>
</ul>
</div>


<div class="content-box">
<p>Thanks for sticking around for the real stuff. This isn't feel-good fluff or social media science. It's what your body and brain actually need.</p>
<p>See you next week!</p>
<p>Cheers,<br>–Max</p>
<hr>
<h2>Rate this week's newsletter on a scale:</h2>
<div class="rating-btn">⭐ Quick Win: Simple, no-fuss tips. I'll do it today.</div>
<div class="rating-btn">⭐⭐ Game Changer: Medium effort, big results. Worth it.</div>
<div class="rating-btn">⭐⭐⭐ Longevity Legend: Big moves for a better future.</div>
</div>


<div class="content-box">
<p style="text-align:center"><strong>ATTENTION: These aren't your usual clickbait headlines.</strong><br>
<span style="font-size:12px">We're diving into peer-reviewed, trustworthy research that could genuinely help you live your best life. No hype, no paid media, just the real deal. <strong>No lower <a href="https://en.wikipedia.org/wiki/Impact_factor">Impact Factor</a> than 2.5.</strong></span></p>
<hr>
<p style="text-align:center;font-size:12px;color:#686868">Curious about how we choose our sources? You can always check out <a href="https://maxhuman.ai">maxhuman.ai</a> for all the nitty-gritty on our methods.</p>
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‍

Weekly Newsletter - March 27

1️⃣ Your Gut Is Aging — And Turning On You

2️⃣ The Molecular Double-Crosser

3️⃣ The Caffeine Cousin That Might Cheat Death

4️⃣ Your Blood Knows Your Brain Is Dying

5️⃣ Reprogramming Cells Is DIY Time Travel

6️⃣ Polyphenols Are Not Optional

7️⃣ WhatsApp Beat Doctors

8️⃣ Your Air Is Cooking Your Brain

9️⃣ The Enzyme Fueling Liver Cancer

🔟 Sleep After 60? A Hot Mess

🛏️ Want to age slower while unconscious?

Rate this week's newsletter on a scale:

Join Thousands on the Path to Wellness.
Subscribe to MaxHuman Today!

Advertise with Us

Weekly Newsletter - March 27

1️⃣ Your Gut Is Aging — And Turning On You

2️⃣ The Molecular Double-Crosser

3️⃣ The Caffeine Cousin That Might Cheat Death

4️⃣ Your Blood Knows Your Brain Is Dying

5️⃣ Reprogramming Cells Is DIY Time Travel

6️⃣ Polyphenols Are Not Optional

7️⃣ WhatsApp Beat Doctors

8️⃣ Your Air Is Cooking Your Brain

9️⃣ The Enzyme Fueling Liver Cancer

🔟 Sleep After 60? A Hot Mess

How Old Is Your Immune System? GlycanAge Knows.

🛏️ Want to age slower while unconscious?

Rate this week's newsletter on a scale:

Join Thousands on the Path to Wellness.Subscribe to MaxHuman Today!

Advertise with Us

Join Thousands on the Path to Wellness.
Subscribe to MaxHuman Today!